Opsin, a structural model for olfactory receptors?
نویسندگان
چکیده
Receptor-ligand interaction: Olfactory receptors (ORs) are G-protein-coupled receptors (GPCRs), which detect signaling molecules such as hormones and odorants. The structure of opsin, the GPCR employed in vision, with a detergent molecule bound deep in its orthosteric ligand-binding pocket provides a template for OR homology modeling, thus enabling investigation of the structural basis of the mechanism of odorant-receptor recognition.
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ورودعنوان ژورنال:
- Angewandte Chemie
دوره 52 42 شماره
صفحات -
تاریخ انتشار 2013